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Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics

Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its t...

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Autores principales: Nuno-Perez, Alvaro, Tchenio, Anna, Mameli, Manuel, Lecca, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064733/
https://www.ncbi.nlm.nih.gov/pubmed/30083090
http://dx.doi.org/10.3389/fnins.2018.00485
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author Nuno-Perez, Alvaro
Tchenio, Anna
Mameli, Manuel
Lecca, Salvatore
author_facet Nuno-Perez, Alvaro
Tchenio, Anna
Mameli, Manuel
Lecca, Salvatore
author_sort Nuno-Perez, Alvaro
collection PubMed
description Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet challenge for modern neuroscience. Evidence from humans and animal models indicate that the lateral habenula (LHb), an epithalamic center devoted to processing aversive stimuli, is aberrantly affected during depression. This raises the hypothesis that rescuing maladaptations within this nucleus may be a potential way to, at least partially, treat aspects of mood disorders. In this review article, we will discuss pre-clinical and clinical evidence highlighting the role of LHb and its cellular adaptations in depression. We will then describe interventional approaches aiming to rescue LHb dysfunction and ultimately ameliorate depressive symptoms. Altogether, we aim to merge the mechanistic-, circuit-, and behavioral-level knowledge obtained about LHb maladaptations in depression to build a general framework that might prove valuable for potential therapeutic interventions.
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spelling pubmed-60647332018-08-06 Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics Nuno-Perez, Alvaro Tchenio, Anna Mameli, Manuel Lecca, Salvatore Front Neurosci Neuroscience Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet challenge for modern neuroscience. Evidence from humans and animal models indicate that the lateral habenula (LHb), an epithalamic center devoted to processing aversive stimuli, is aberrantly affected during depression. This raises the hypothesis that rescuing maladaptations within this nucleus may be a potential way to, at least partially, treat aspects of mood disorders. In this review article, we will discuss pre-clinical and clinical evidence highlighting the role of LHb and its cellular adaptations in depression. We will then describe interventional approaches aiming to rescue LHb dysfunction and ultimately ameliorate depressive symptoms. Altogether, we aim to merge the mechanistic-, circuit-, and behavioral-level knowledge obtained about LHb maladaptations in depression to build a general framework that might prove valuable for potential therapeutic interventions. Frontiers Media S.A. 2018-07-23 /pmc/articles/PMC6064733/ /pubmed/30083090 http://dx.doi.org/10.3389/fnins.2018.00485 Text en Copyright © 2018 Nuno-Perez, Tchenio, Mameli and Lecca. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Nuno-Perez, Alvaro
Tchenio, Anna
Mameli, Manuel
Lecca, Salvatore
Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title_full Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title_fullStr Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title_full_unstemmed Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title_short Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics
title_sort lateral habenula gone awry in depression: bridging cellular adaptations with therapeutics
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064733/
https://www.ncbi.nlm.nih.gov/pubmed/30083090
http://dx.doi.org/10.3389/fnins.2018.00485
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