Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

BACKGROUND: Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. METHODS AND RESULTS: Cardi...

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Detalles Bibliográficos
Autores principales: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Peretik, Jonette M., Orr, A. Wayne, James, Jeanne, Robbins, Jeffrey, Bhuiyan, Md. Shenuarin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://www.ncbi.nlm.nih.gov/pubmed/29987122
http://dx.doi.org/10.1161/JAHA.118.009289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://www.ncbi.nlm.nih.gov/pubmed/29987122
http://dx.doi.org/10.1161/JAHA.118.009289

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