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Discovery of an Experimental Model of Unicuspid Aortic Valve

BACKGROUND: The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss‐of‐function mutation in epithelial growth factor receptor, which are Egfr (Vel/+) mice, would develop anomalous a...

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Detalles Bibliográficos
Autores principales:	Weiss, Robert M., Chu, Yi, Brooks, Robert M., Lund, Donald D., Cheng, Justine, Zimmerman, Kathy A., Kafa, Melissa K., Sistla, Phanicharan, Doshi, Hardik, Shao, Jian Q., El Accaoui, Ramzi N., Otto, Catherine M., Heistad, Donald D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064885/ https://www.ncbi.nlm.nih.gov/pubmed/29960994 http://dx.doi.org/10.1161/JAHA.117.006908

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