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Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts

BACKGROUND: Insulin resistance in diabetes mellitus has been associated with mitochondrial dysfunction. Defects at the level of mitochondria are also characteristic of heart failure. We assessed changes in cardiac insulin response and mitochondrial function in a model of pressure overload‐induced he...

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Detalles Bibliográficos
Autores principales:	Nguyen, T. Dung, Schwarzer, Michael, Schrepper, Andrea, Amorim, Paulo A., Blum, Daniel, Hain, Claudia, Faerber, Gloria, Haendeler, Judith, Altschmied, Joachim, Doenst, Torsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064925/ https://www.ncbi.nlm.nih.gov/pubmed/29929988 http://dx.doi.org/10.1161/JAHA.118.008865

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