Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice

Aim: In this study, Staphylococcus phage JD007 bactericidal activity and induced immune responses during treatment were assessed in a dermal abscess model. Materials and Methods: Dermal abscesses in nude mice were established by injecting a clinical isolate of S. aureus SA325 isolated from the back...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Bingyu, Li, Qingtian, Guo, Mingquan, Dong, Ke, Zhang, Yan, Guo, Xiaokui, Liu, Qingzhong, Li, Li, Cui, Zelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064926/
https://www.ncbi.nlm.nih.gov/pubmed/30083139
http://dx.doi.org/10.3389/fmicb.2018.01553
_version_ 1783342783158812672
author Ding, Bingyu
Li, Qingtian
Guo, Mingquan
Dong, Ke
Zhang, Yan
Guo, Xiaokui
Liu, Qingzhong
Li, Li
Cui, Zelin
author_facet Ding, Bingyu
Li, Qingtian
Guo, Mingquan
Dong, Ke
Zhang, Yan
Guo, Xiaokui
Liu, Qingzhong
Li, Li
Cui, Zelin
author_sort Ding, Bingyu
collection PubMed
description Aim: In this study, Staphylococcus phage JD007 bactericidal activity and induced immune responses during treatment were assessed in a dermal abscess model. Materials and Methods: Dermal abscesses in nude mice were established by injecting a clinical isolate of S. aureus SA325 isolated from the back under-dermal abscess of an in-patient. Results: Phage JD007 was able to inhibit the growth of S. aureus SA325 at MOI = 1 or 10, significantly preventing the formation of dermal abscesses. Moderate immune responses were observed in the prevention group through detection of cytokines. Conclusion: Phage JD007 inhibits the formation of dermal abscesses caused by a clinical S. aureus strain in nude mice without robust immune responses.
format Online
Article
Text
id pubmed-6064926
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-60649262018-08-06 Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice Ding, Bingyu Li, Qingtian Guo, Mingquan Dong, Ke Zhang, Yan Guo, Xiaokui Liu, Qingzhong Li, Li Cui, Zelin Front Microbiol Microbiology Aim: In this study, Staphylococcus phage JD007 bactericidal activity and induced immune responses during treatment were assessed in a dermal abscess model. Materials and Methods: Dermal abscesses in nude mice were established by injecting a clinical isolate of S. aureus SA325 isolated from the back under-dermal abscess of an in-patient. Results: Phage JD007 was able to inhibit the growth of S. aureus SA325 at MOI = 1 or 10, significantly preventing the formation of dermal abscesses. Moderate immune responses were observed in the prevention group through detection of cytokines. Conclusion: Phage JD007 inhibits the formation of dermal abscesses caused by a clinical S. aureus strain in nude mice without robust immune responses. Frontiers Media S.A. 2018-07-23 /pmc/articles/PMC6064926/ /pubmed/30083139 http://dx.doi.org/10.3389/fmicb.2018.01553 Text en Copyright © 2018 Ding, Li, Guo, Dong, Zhang, Guo, Liu, Li and Cui. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ding, Bingyu
Li, Qingtian
Guo, Mingquan
Dong, Ke
Zhang, Yan
Guo, Xiaokui
Liu, Qingzhong
Li, Li
Cui, Zelin
Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title_full Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title_fullStr Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title_full_unstemmed Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title_short Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
title_sort prevention of dermal abscess formation caused by staphylococcus aureus using phage jd007 in nude mice
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064926/
https://www.ncbi.nlm.nih.gov/pubmed/30083139
http://dx.doi.org/10.3389/fmicb.2018.01553
work_keys_str_mv AT dingbingyu preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT liqingtian preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT guomingquan preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT dongke preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT zhangyan preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT guoxiaokui preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT liuqingzhong preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT lili preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice
AT cuizelin preventionofdermalabscessformationcausedbystaphylococcusaureususingphagejd007innudemice

Ejemplares similares