PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect

Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson’s disease (PD). We report that the Bin/Amphiphysin/Rvs (BAR) domain of protein interacting with PRKCA1 (PICK1) bound to the really interesting new gene 1 (RING1...

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Detalles Bibliográficos
Autores principales: He, Jing, Xia, Mengying, Yeung, Patrick K. K., Li, Jiahua, Li, Zhifang, Chung, Kenny K., Chung, Sookja K., Xia, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064985/
https://www.ncbi.nlm.nih.gov/pubmed/29987020
http://dx.doi.org/10.1073/pnas.1716506115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064985/
https://www.ncbi.nlm.nih.gov/pubmed/29987020
http://dx.doi.org/10.1073/pnas.1716506115

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