CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 receptor on T cells to suppress their function. We show that binding of CD52-Fc to Siglec-10 and T cell suppression...

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Detalles Bibliográficos
Autores principales: Bandala-Sanchez, Esther, G. Bediaga, Naiara, Goddard-Borger, Ethan D., Ngui, Katrina, Naselli, Gaetano, Stone, Natalie L., Neale, Alana M., Pearce, Lesley A., Wardak, Ahmad, Czabotar, Peter, Haselhorst, Thomas, Maggioni, Andrea, Hartley-Tassell, Lauren A., Adams, Timothy E., Harrison, Leonard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065011/
https://www.ncbi.nlm.nih.gov/pubmed/29997173
http://dx.doi.org/10.1073/pnas.1722056115

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