Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

The diverse physiological roles of the neurotrophin family have long prompted exploration of their potential as therapeutic agents for nerve injury and neurodegenerative diseases. To date, clinical trials of one family member, brain-derived neurotrophic factor (BDNF), have disappointingly failed to...

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Detalles Bibliográficos
Autores principales: Merkouris, Spyros, Barde, Yves-Alain, Binley, Kate E., Allen, Nicholas D., Stepanov, Alexey V., Wu, Nicholas C., Grande, Geramie, Lin, Chih-Wei, Li, Meng, Nan, Xinsheng, Chacon-Fernandez, Pedro, DiStefano, Peter S., Lindsay, Ronald M., Lerner, Richard A., Xie, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065019/
https://www.ncbi.nlm.nih.gov/pubmed/29987039
http://dx.doi.org/10.1073/pnas.1806660115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065019/
https://www.ncbi.nlm.nih.gov/pubmed/29987039
http://dx.doi.org/10.1073/pnas.1806660115

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