A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl

BACKGROUND: Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality. CASE PRESENTATION: We present a case of a 13 -year old girl with severe cerebral edema secondary to acet...

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Autores principales: Austin, Emily B., Hobbs, Hailey, Crouse, Brian A., Lobos, Anna-Theresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065149/
https://www.ncbi.nlm.nih.gov/pubmed/30060738
http://dx.doi.org/10.1186/s12887-018-1233-5
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author Austin, Emily B.
Hobbs, Hailey
Crouse, Brian A.
Lobos, Anna-Theresa
author_facet Austin, Emily B.
Hobbs, Hailey
Crouse, Brian A.
Lobos, Anna-Theresa
author_sort Austin, Emily B.
collection PubMed
description BACKGROUND: Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality. CASE PRESENTATION: We present a case of a 13 -year old girl with severe cerebral edema secondary to acetaminophen toxicity and hepatic failure. Her poor neurological status precluded her from liver transplantation and withdrawal of life sustaining treatment was recommended. However, with supportive care, she remarkably made a full recovery. CONCLUSIONS: This case highlights the difficulties surrounding prognostication in pediatric patients with cerebral edema from acute liver failure secondary to acetaminophen toxicity.
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spelling pubmed-60651492018-08-01 A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl Austin, Emily B. Hobbs, Hailey Crouse, Brian A. Lobos, Anna-Theresa BMC Pediatr Case Report BACKGROUND: Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality. CASE PRESENTATION: We present a case of a 13 -year old girl with severe cerebral edema secondary to acetaminophen toxicity and hepatic failure. Her poor neurological status precluded her from liver transplantation and withdrawal of life sustaining treatment was recommended. However, with supportive care, she remarkably made a full recovery. CONCLUSIONS: This case highlights the difficulties surrounding prognostication in pediatric patients with cerebral edema from acute liver failure secondary to acetaminophen toxicity. BioMed Central 2018-07-30 /pmc/articles/PMC6065149/ /pubmed/30060738 http://dx.doi.org/10.1186/s12887-018-1233-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Austin, Emily B.
Hobbs, Hailey
Crouse, Brian A.
Lobos, Anna-Theresa
A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title_full A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title_fullStr A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title_full_unstemmed A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title_short A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
title_sort case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065149/
https://www.ncbi.nlm.nih.gov/pubmed/30060738
http://dx.doi.org/10.1186/s12887-018-1233-5
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