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Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability

In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polyco...

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Autores principales: Dardalhon-Cuménal, Delphine, Deraze, Jérôme, Dupont, Camille A., Ribeiro, Valérie, Coléno-Costes, Anne, Pouch, Juliette, Le Crom, Stéphane, Thomassin, Hélène, Debat, Vincent, Randsholt, Neel B., Peronnet, Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065198/
https://www.ncbi.nlm.nih.gov/pubmed/29995890
http://dx.doi.org/10.1371/journal.pgen.1007498
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author Dardalhon-Cuménal, Delphine
Deraze, Jérôme
Dupont, Camille A.
Ribeiro, Valérie
Coléno-Costes, Anne
Pouch, Juliette
Le Crom, Stéphane
Thomassin, Hélène
Debat, Vincent
Randsholt, Neel B.
Peronnet, Frédérique
author_facet Dardalhon-Cuménal, Delphine
Deraze, Jérôme
Dupont, Camille A.
Ribeiro, Valérie
Coléno-Costes, Anne
Pouch, Juliette
Le Crom, Stéphane
Thomassin, Hélène
Debat, Vincent
Randsholt, Neel B.
Peronnet, Frédérique
author_sort Dardalhon-Cuménal, Delphine
collection PubMed
description In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polycomb (ETP) and Polycomb families. This led us to investigate the importance of these interactions in developmental stability. Deregulation of Cyclin G highlights an organ intrinsic control of developmental noise, linked to the ETP-interacting domain, and enhanced by mutations in genes encoding members of the Polycomb Repressive complexes PRC1 and PR-DUB. Deep-sequencing of wing imaginal discs deregulating CycG reveals that high developmental noise correlates with up-regulation of genes involved in translation and down-regulation of genes involved in energy production. Most Cyclin G direct transcriptional targets are also direct targets of PRC1 and RNAPolII in the developing wing. Altogether, our results suggest that Cyclin G, PRC1 and PR-DUB cooperate for developmental stability.
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spelling pubmed-60651982018-08-13 Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability Dardalhon-Cuménal, Delphine Deraze, Jérôme Dupont, Camille A. Ribeiro, Valérie Coléno-Costes, Anne Pouch, Juliette Le Crom, Stéphane Thomassin, Hélène Debat, Vincent Randsholt, Neel B. Peronnet, Frédérique PLoS Genet Research Article In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polycomb (ETP) and Polycomb families. This led us to investigate the importance of these interactions in developmental stability. Deregulation of Cyclin G highlights an organ intrinsic control of developmental noise, linked to the ETP-interacting domain, and enhanced by mutations in genes encoding members of the Polycomb Repressive complexes PRC1 and PR-DUB. Deep-sequencing of wing imaginal discs deregulating CycG reveals that high developmental noise correlates with up-regulation of genes involved in translation and down-regulation of genes involved in energy production. Most Cyclin G direct transcriptional targets are also direct targets of PRC1 and RNAPolII in the developing wing. Altogether, our results suggest that Cyclin G, PRC1 and PR-DUB cooperate for developmental stability. Public Library of Science 2018-07-11 /pmc/articles/PMC6065198/ /pubmed/29995890 http://dx.doi.org/10.1371/journal.pgen.1007498 Text en © 2018 Dardalhon-Cuménal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dardalhon-Cuménal, Delphine
Deraze, Jérôme
Dupont, Camille A.
Ribeiro, Valérie
Coléno-Costes, Anne
Pouch, Juliette
Le Crom, Stéphane
Thomassin, Hélène
Debat, Vincent
Randsholt, Neel B.
Peronnet, Frédérique
Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title_full Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title_fullStr Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title_full_unstemmed Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title_short Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
title_sort cyclin g and the polycomb repressive complexes prc1 and pr-dub cooperate for developmental stability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065198/
https://www.ncbi.nlm.nih.gov/pubmed/29995890
http://dx.doi.org/10.1371/journal.pgen.1007498
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