Cargando…

5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report

BACKGROUND: Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION: A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking...

Descripción completa

Detalles Bibliográficos
Autores principales: McGlinchey, Paul G, Webb, Stephen T, Campbell, Norman PS
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60652/
https://www.ncbi.nlm.nih.gov/pubmed/11734065
http://dx.doi.org/10.1186/1471-2261-1-3
_version_ 1782120118737698816
author McGlinchey, Paul G
Webb, Stephen T
Campbell, Norman PS
author_facet McGlinchey, Paul G
Webb, Stephen T
Campbell, Norman PS
author_sort McGlinchey, Paul G
collection PubMed
description BACKGROUND: Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION: A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highlighting the severity of the presentation are included in the report along with coronary angiograms demonstrating the absence of significant coronary atherosclerosis. CONCLUSION: Severe 5-fluorouracil-induced cardiotoxicity is rare, but can be severe and may mimic acute myocardial infarction, leading to diagnostic and therapeutic dilemmas. Readministration of 5-fluorouracil is not advised following an episode of cardiotoxicity.
format Text
id pubmed-60652
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-606522001-12-09 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report McGlinchey, Paul G Webb, Stephen T Campbell, Norman PS BMC Cardiovasc Disord Case Report BACKGROUND: Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION: A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highlighting the severity of the presentation are included in the report along with coronary angiograms demonstrating the absence of significant coronary atherosclerosis. CONCLUSION: Severe 5-fluorouracil-induced cardiotoxicity is rare, but can be severe and may mimic acute myocardial infarction, leading to diagnostic and therapeutic dilemmas. Readministration of 5-fluorouracil is not advised following an episode of cardiotoxicity. BioMed Central 2001-11-22 /pmc/articles/PMC60652/ /pubmed/11734065 http://dx.doi.org/10.1186/1471-2261-1-3 Text en Copyright © 2001 McGlinchey et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Case Report
McGlinchey, Paul G
Webb, Stephen T
Campbell, Norman PS
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title_full 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title_fullStr 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title_full_unstemmed 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title_short 5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
title_sort 5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60652/
https://www.ncbi.nlm.nih.gov/pubmed/11734065
http://dx.doi.org/10.1186/1471-2261-1-3
work_keys_str_mv AT mcglincheypaulg 5fluorouracilinducedcardiotoxicitymimickingmyocardialinfarctionacasereport
AT webbstephent 5fluorouracilinducedcardiotoxicitymimickingmyocardialinfarctionacasereport
AT campbellnormanps 5fluorouracilinducedcardiotoxicitymimickingmyocardialinfarctionacasereport