Cargando…
Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury
Decompression is the major therapeutic strategy for acute spinal cord injury, but there is some debate about the time window for decompression following spinal cord injury. An important goal and challenge in the treatment of spinal cord injury is inhibiting or reversing secondary injury. Governor Ve...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065222/ https://www.ncbi.nlm.nih.gov/pubmed/30028333 http://dx.doi.org/10.4103/1673-5374.235062 |
_version_ | 1783342821397233664 |
---|---|
author | Wang, Yan-Lei Qi, Ying-Na Wang, Wei Dong, Chun-Ke Yi, Ping Yang, Feng Tang, Xiang-Sheng Tan, Ming-Sheng |
author_facet | Wang, Yan-Lei Qi, Ying-Na Wang, Wei Dong, Chun-Ke Yi, Ping Yang, Feng Tang, Xiang-Sheng Tan, Ming-Sheng |
author_sort | Wang, Yan-Lei |
collection | PubMed |
description | Decompression is the major therapeutic strategy for acute spinal cord injury, but there is some debate about the time window for decompression following spinal cord injury. An important goal and challenge in the treatment of spinal cord injury is inhibiting or reversing secondary injury. Governor Vessel electroacupuncture can improve symptoms of spinal cord injury by inhibiting cell apoptosis and improving the microenvironment of the injured spinal cord. In this study, Governor Vessel electroacupuncture combined with decompression at different time points was used to treat acute spinal cord injury. The rat models were established by inserting a balloon catheter into the atlanto-occipital space. The upper cervical spinal cord was compressed for 12 or 48 hours prior to decompression. Electroacupuncture was conducted at the acupoints Dazhui (GV14) and Baihui (GV 20) (2 Hz, 15 minutes) once a day for 14 consecutive days. Compared with decompression alone, hind limb motor function recovery was superior after decompression for 12 and 48 hours combined with electroacupuncture. However, the recovery of motor function was not significantly different at 14 days after treatment in rats receiving decompression for 12 hours. Platelet-activating factor levels and caspase-9 protein expression were significantly reduced in rats receiving electroacupuncture compared with decompression alone. These findings indicate that compared with decompression alone, Governor Vessel electroacupuncture combined with delayed decompression (48 hours) is more effective in the treatment of upper cervical spinal cord injury. Governor Vessel electroacupuncture combined with early decompression (12 hours) can accelerate the recovery of nerve movement in rats with upper cervical spinal cord injury. Nevertheless, further studies are necessary to confirm whether it is possible to obtain additional benefit compared with early decompression alone. |
format | Online Article Text |
id | pubmed-6065222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60652222018-08-09 Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury Wang, Yan-Lei Qi, Ying-Na Wang, Wei Dong, Chun-Ke Yi, Ping Yang, Feng Tang, Xiang-Sheng Tan, Ming-Sheng Neural Regen Res Research Article Decompression is the major therapeutic strategy for acute spinal cord injury, but there is some debate about the time window for decompression following spinal cord injury. An important goal and challenge in the treatment of spinal cord injury is inhibiting or reversing secondary injury. Governor Vessel electroacupuncture can improve symptoms of spinal cord injury by inhibiting cell apoptosis and improving the microenvironment of the injured spinal cord. In this study, Governor Vessel electroacupuncture combined with decompression at different time points was used to treat acute spinal cord injury. The rat models were established by inserting a balloon catheter into the atlanto-occipital space. The upper cervical spinal cord was compressed for 12 or 48 hours prior to decompression. Electroacupuncture was conducted at the acupoints Dazhui (GV14) and Baihui (GV 20) (2 Hz, 15 minutes) once a day for 14 consecutive days. Compared with decompression alone, hind limb motor function recovery was superior after decompression for 12 and 48 hours combined with electroacupuncture. However, the recovery of motor function was not significantly different at 14 days after treatment in rats receiving decompression for 12 hours. Platelet-activating factor levels and caspase-9 protein expression were significantly reduced in rats receiving electroacupuncture compared with decompression alone. These findings indicate that compared with decompression alone, Governor Vessel electroacupuncture combined with delayed decompression (48 hours) is more effective in the treatment of upper cervical spinal cord injury. Governor Vessel electroacupuncture combined with early decompression (12 hours) can accelerate the recovery of nerve movement in rats with upper cervical spinal cord injury. Nevertheless, further studies are necessary to confirm whether it is possible to obtain additional benefit compared with early decompression alone. Medknow Publications & Media Pvt Ltd 2018-07 /pmc/articles/PMC6065222/ /pubmed/30028333 http://dx.doi.org/10.4103/1673-5374.235062 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Wang, Yan-Lei Qi, Ying-Na Wang, Wei Dong, Chun-Ke Yi, Ping Yang, Feng Tang, Xiang-Sheng Tan, Ming-Sheng Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title | Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title_full | Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title_fullStr | Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title_full_unstemmed | Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title_short | Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
title_sort | effects of decompression joint governor vessel electro-acupuncture on rats with acute upper cervical spinal cord injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065222/ https://www.ncbi.nlm.nih.gov/pubmed/30028333 http://dx.doi.org/10.4103/1673-5374.235062 |
work_keys_str_mv | AT wangyanlei effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT qiyingna effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT wangwei effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT dongchunke effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT yiping effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT yangfeng effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT tangxiangsheng effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury AT tanmingsheng effectsofdecompressionjointgovernorvesselelectroacupunctureonratswithacuteuppercervicalspinalcordinjury |