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The Complexity of Piroplasms Life Cycles

Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from la...

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Autores principales: Jalovecka, Marie, Hajdusek, Ondrej, Sojka, Daniel, Kopacek, Petr, Malandrin, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065256/
https://www.ncbi.nlm.nih.gov/pubmed/30083518
http://dx.doi.org/10.3389/fcimb.2018.00248
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author Jalovecka, Marie
Hajdusek, Ondrej
Sojka, Daniel
Kopacek, Petr
Malandrin, Laurence
author_facet Jalovecka, Marie
Hajdusek, Ondrej
Sojka, Daniel
Kopacek, Petr
Malandrin, Laurence
author_sort Jalovecka, Marie
collection PubMed
description Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from large numbers of newly described species. This review intends to collate and summarize current knowledge with respect to piroplasm phylogeny. Moreover, it provides a comprehensive view of developmental events of Babesia, Theileria, and Cytauxzoon representative species, focusing on uniform consensus of three consecutive phases: (i) schizogony and merogony, asexual multiplication in blood cells of the vertebrate host; (ii) gamogony, sexual reproduction inside the tick midgut, later followed by invasion of kinetes into the tick internal tissues; and (iii) sporogony, asexual proliferation in tick salivary glands resulting in the formation of sporozoites. However, many fundamental differences in this general consensus occur and this review identifies variables that should be analyzed prior to further development of specific anti-piroplasm strategies, including the attractive targeting of life cycle stages of Babesia or Theileria tick vectors.
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spelling pubmed-60652562018-08-06 The Complexity of Piroplasms Life Cycles Jalovecka, Marie Hajdusek, Ondrej Sojka, Daniel Kopacek, Petr Malandrin, Laurence Front Cell Infect Microbiol Cellular and Infection Microbiology Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from large numbers of newly described species. This review intends to collate and summarize current knowledge with respect to piroplasm phylogeny. Moreover, it provides a comprehensive view of developmental events of Babesia, Theileria, and Cytauxzoon representative species, focusing on uniform consensus of three consecutive phases: (i) schizogony and merogony, asexual multiplication in blood cells of the vertebrate host; (ii) gamogony, sexual reproduction inside the tick midgut, later followed by invasion of kinetes into the tick internal tissues; and (iii) sporogony, asexual proliferation in tick salivary glands resulting in the formation of sporozoites. However, many fundamental differences in this general consensus occur and this review identifies variables that should be analyzed prior to further development of specific anti-piroplasm strategies, including the attractive targeting of life cycle stages of Babesia or Theileria tick vectors. Frontiers Media S.A. 2018-07-23 /pmc/articles/PMC6065256/ /pubmed/30083518 http://dx.doi.org/10.3389/fcimb.2018.00248 Text en Copyright © 2018 Jalovecka, Hajdusek, Sojka, Kopacek and Malandrin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Jalovecka, Marie
Hajdusek, Ondrej
Sojka, Daniel
Kopacek, Petr
Malandrin, Laurence
The Complexity of Piroplasms Life Cycles
title The Complexity of Piroplasms Life Cycles
title_full The Complexity of Piroplasms Life Cycles
title_fullStr The Complexity of Piroplasms Life Cycles
title_full_unstemmed The Complexity of Piroplasms Life Cycles
title_short The Complexity of Piroplasms Life Cycles
title_sort complexity of piroplasms life cycles
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065256/
https://www.ncbi.nlm.nih.gov/pubmed/30083518
http://dx.doi.org/10.3389/fcimb.2018.00248
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