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The Complexity of Piroplasms Life Cycles
Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from la...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065256/ https://www.ncbi.nlm.nih.gov/pubmed/30083518 http://dx.doi.org/10.3389/fcimb.2018.00248 |
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author | Jalovecka, Marie Hajdusek, Ondrej Sojka, Daniel Kopacek, Petr Malandrin, Laurence |
author_facet | Jalovecka, Marie Hajdusek, Ondrej Sojka, Daniel Kopacek, Petr Malandrin, Laurence |
author_sort | Jalovecka, Marie |
collection | PubMed |
description | Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from large numbers of newly described species. This review intends to collate and summarize current knowledge with respect to piroplasm phylogeny. Moreover, it provides a comprehensive view of developmental events of Babesia, Theileria, and Cytauxzoon representative species, focusing on uniform consensus of three consecutive phases: (i) schizogony and merogony, asexual multiplication in blood cells of the vertebrate host; (ii) gamogony, sexual reproduction inside the tick midgut, later followed by invasion of kinetes into the tick internal tissues; and (iii) sporogony, asexual proliferation in tick salivary glands resulting in the formation of sporozoites. However, many fundamental differences in this general consensus occur and this review identifies variables that should be analyzed prior to further development of specific anti-piroplasm strategies, including the attractive targeting of life cycle stages of Babesia or Theileria tick vectors. |
format | Online Article Text |
id | pubmed-6065256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60652562018-08-06 The Complexity of Piroplasms Life Cycles Jalovecka, Marie Hajdusek, Ondrej Sojka, Daniel Kopacek, Petr Malandrin, Laurence Front Cell Infect Microbiol Cellular and Infection Microbiology Although apicomplexan parasites of the group Piroplasmida represent commonly identified global risks to both animals and humans, detailed knowledge of their life cycles is surprisingly limited. Such a discrepancy results from incomplete literature reports, nomenclature disunity and recently, from large numbers of newly described species. This review intends to collate and summarize current knowledge with respect to piroplasm phylogeny. Moreover, it provides a comprehensive view of developmental events of Babesia, Theileria, and Cytauxzoon representative species, focusing on uniform consensus of three consecutive phases: (i) schizogony and merogony, asexual multiplication in blood cells of the vertebrate host; (ii) gamogony, sexual reproduction inside the tick midgut, later followed by invasion of kinetes into the tick internal tissues; and (iii) sporogony, asexual proliferation in tick salivary glands resulting in the formation of sporozoites. However, many fundamental differences in this general consensus occur and this review identifies variables that should be analyzed prior to further development of specific anti-piroplasm strategies, including the attractive targeting of life cycle stages of Babesia or Theileria tick vectors. Frontiers Media S.A. 2018-07-23 /pmc/articles/PMC6065256/ /pubmed/30083518 http://dx.doi.org/10.3389/fcimb.2018.00248 Text en Copyright © 2018 Jalovecka, Hajdusek, Sojka, Kopacek and Malandrin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Jalovecka, Marie Hajdusek, Ondrej Sojka, Daniel Kopacek, Petr Malandrin, Laurence The Complexity of Piroplasms Life Cycles |
title | The Complexity of Piroplasms Life Cycles |
title_full | The Complexity of Piroplasms Life Cycles |
title_fullStr | The Complexity of Piroplasms Life Cycles |
title_full_unstemmed | The Complexity of Piroplasms Life Cycles |
title_short | The Complexity of Piroplasms Life Cycles |
title_sort | complexity of piroplasms life cycles |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065256/ https://www.ncbi.nlm.nih.gov/pubmed/30083518 http://dx.doi.org/10.3389/fcimb.2018.00248 |
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