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Metagenomic mining of regulatory elements enables programmable species-selective gene expression
Robust and predictably performing synthetic circuits rely on the use of well-characterized regulatory parts across different genetic backgrounds and environmental contexts. Here, we report the large-scale metagenomic mining of thousands of natural 5′-regulatory sequences from diverse bacteria and th...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065261/ https://www.ncbi.nlm.nih.gov/pubmed/30052624 http://dx.doi.org/10.1038/nmeth.4633 |