A critical view on transgenerational epigenetic inheritance in humans

Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of t...

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Autor principal: Horsthemke, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065375/
https://www.ncbi.nlm.nih.gov/pubmed/30061690
http://dx.doi.org/10.1038/s41467-018-05445-5
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author Horsthemke, Bernhard
author_facet Horsthemke, Bernhard
author_sort Horsthemke, Bernhard
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description Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.
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spelling pubmed-60653752018-07-31 A critical view on transgenerational epigenetic inheritance in humans Horsthemke, Bernhard Nat Commun Comment Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies. Nature Publishing Group UK 2018-07-30 /pmc/articles/PMC6065375/ /pubmed/30061690 http://dx.doi.org/10.1038/s41467-018-05445-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Horsthemke, Bernhard
A critical view on transgenerational epigenetic inheritance in humans
title A critical view on transgenerational epigenetic inheritance in humans
title_full A critical view on transgenerational epigenetic inheritance in humans
title_fullStr A critical view on transgenerational epigenetic inheritance in humans
title_full_unstemmed A critical view on transgenerational epigenetic inheritance in humans
title_short A critical view on transgenerational epigenetic inheritance in humans
title_sort critical view on transgenerational epigenetic inheritance in humans
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065375/
https://www.ncbi.nlm.nih.gov/pubmed/30061690
http://dx.doi.org/10.1038/s41467-018-05445-5
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