Cargando…

In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington’s disease

Neurodegenerative diseases, characterised by the progressive and selective neuronal death in the central nervous system, are frequently accompanied by an activated immune system. In Huntington’s disease (HD), clinical and animal studies show evidence of immune activity, along with hyper-reactive mon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pido-Lopez, Jeffrey, Andre, Ralph, Benjamin, Agnesska C., Ali, Nadira, Farag, Sahar, Tabrizi, Sarah J., Bates, Gillian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065433/ https://www.ncbi.nlm.nih.gov/pubmed/30061661 http://dx.doi.org/10.1038/s41598-018-29792-x

Ejemplares similares

Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington’s disease by etanercept treatment
por: Pido-Lopez, Jeffrey, et al.
Publicado: (2019)

Monocytes and Macrophages as Protagonists in Vascular Complications of Diabetes
por: Kanter, Jenny E., et al.
Publicado: (2020)

Neutrophils as emerging protagonists and targets in chronic inflammatory diseases
por: Rawat, Kavita, et al.
Publicado: (2022)

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice
por: Tulino, Raffaella, et al.
Publicado: (2016)

Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice
por: Tulino, Raffaella, et al.
Publicado: (2016)

Mitochondria at the extremes: pioneers, protectorates, protagonists
por: Murray, Andrew J
Publicado: (2014)

Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach
por: Barrett, Hilary E., et al.
Publicado: (2020)

Wild-type huntingtin regulates human macrophage function
por: O’Regan, Grace C., et al.
Publicado: (2020)

Extracellular Vesicles as Protagonists of Diabetic Cardiovascular Pathology
por: Gustafson, Dakota, et al.
Publicado: (2017)

Bacteriophages: Protagonists of a Post-Antibiotic Era
por: Domingo-Calap, Pilar, et al.
Publicado: (2018)

Neutrophils as a Protagonist and Target in Chronic Rhinosinusitis
por: Wang, Hai, et al.
Publicado: (2019)

CD137(+) T-Cells: Protagonists of the Immunotherapy Revolution
por: Ugolini, Alessio, et al.
Publicado: (2021)

The “Microbiome”: A Protagonist in COVID-19 Era
por: Merra, Giuseppe, et al.
Publicado: (2022)

Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
por: Martinez-Zubiaurre, Inigo, et al.
Publicado: (2023)

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons
por: Lange, Jenny, et al.
Publicado: (2021)

Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
por: O’Regan, Grace C., et al.
Publicado: (2021)

AZITHROMYCIN IN ACNE: A PROTAGONIST FOR FIXED DRUG REACTION?
por: Gahalaut, Pratik, et al.
Publicado: (2008)

Editorial: the changing faces of glutathione, a cellular protagonist
por: Pompella, Alfonso, et al.
Publicado: (2015)

JAK2 in Myeloproliferative Neoplasms: Still a Protagonist
por: Bader, Michael Stephan, et al.
Publicado: (2022)

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice
por: Bondulich, Marie K., et al.
Publicado: (2017)

Sir Kenelm Digby, Writer, Bibliophile, and Protagonist of William Harvey
por: Smith, George H.
Publicado: (1938)

The JAK2 gene as a protagonist in chronic myeloproliferative neoplasms
por: de Freitas, Renata Mendes, et al.
Publicado: (2013)

Amphiphile-Based Complex Fluids: The Self-Assembly Ensemble as Protagonist
por: Clark, Aurora E.
Publicado: (2018)

Integrated Care’s New Protagonist: The Expanding Role of Digital Health
por: Steele Gray, Carolyn
Publicado: (2021)

The Endothelium, A Protagonist in the Pathophysiology of Critical Illness: Focus on Cellular Markers
por: van Ierssel, Sabrina H., et al.
Publicado: (2014)

FUBP1: a new protagonist in splicing regulation of the DMD gene
por: Miro, Julie, et al.
Publicado: (2015)

The Three “Musketairs” – Lasker Prize 2016 goes to the protagonists of hypoxia research
por: Wenger, Roland H, et al.
Publicado: (2016)

The female geriatric proximal humeral fracture: protagonist for straight antegrade nailing?
por: Lindtner, Richard A., et al.
Publicado: (2017)

Contextual knowledge provided by a movie biases implicit perception of the protagonist
por: Afdile, Mamdooh, et al.
Publicado: (2019)

Innate immune cells, major protagonists of sickle cell disease pathophysiology
por: Allali, Slimane, et al.
Publicado: (2020)

Violence Depicted in Superhero-Based Films Stratified by Protagonist/Antagonist and Gender
por: Muller, John N, et al.
Publicado: (2020)

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution
por: Parsons, Richard B., et al.
Publicado: (2021)

Spirituality in Patients at the End of Life—Is It Necessary? A Qualitative Approach to the Protagonists
por: García-Navarro, E. Begoña, et al.
Publicado: (2021)

Still a threatening opioid wave: it is time for the protagonist to step up!
por: Lee, Joon-Ho
Publicado: (2023)

The Gut–Vascular Barrier as a New Protagonist in Intestinal and Extraintestinal Diseases
por: Di Tommaso, Natalia, et al.
Publicado: (2023)

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models
por: Träger, Ulrike, et al.
Publicado: (2015)

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington’s Disease T Lymphocytes
por: Miller, James R. C., et al.
Publicado: (2015)

Epstein–Barr virus gene expression in human breast cancer: protagonist or passenger?
por: Xue, S A, et al.
Publicado: (2003)

Protagonist Role of Opioidergic System on Post-Traumatic Stress Disorder and Associated Pain
por: Nikbakhtzadeh, Marjan, et al.
Publicado: (2020)

Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington’s disease
por: Manivannan, Ashwinee, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_68mhrjccghj0skfpul24i36na1