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Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies
BACKGROUND: The enzymes involved in de novo purine synthesis (DNPS), one of the basic processes in eukaryotic cells, transiently and reversibly form a dynamic multienzyme complex called the purinosome in the cytoplasm. The purinosome has been observed in a broad spectrum of cells, but some studies c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066232/ https://www.ncbi.nlm.nih.gov/pubmed/30059557 http://dx.doi.org/10.1371/journal.pone.0201432 |