Cargando…

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei

The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between hosts as well as survival within them and involves strict regulation of mitoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dewar, Caroline E., MacGregor, Paula, Cooper, Sinclair, Gould, Matthew K., Matthews, Keith R., Savill, Nicholas J., Schnaufer, Achim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066258/ https://www.ncbi.nlm.nih.gov/pubmed/30020996 http://dx.doi.org/10.1371/journal.ppat.1007195

Ejemplares similares

Organization of minicircle cassettes and guide RNA genes in Trypanosoma brucei
por: Cooper, Sinclair, et al.
Publicado: (2022)

Assembly and annotation of the mitochondrial minicircle genome of a differentiation-competent strain of Trypanosoma brucei
por: Cooper, Sinclair, et al.
Publicado: (2019)

Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei
por: MacGregor, Paula, et al.
Publicado: (2012)

Independence from Kinetoplast DNA Maintenance and Expression Is Associated with Multidrug Resistance in Trypanosoma brucei In Vitro
por: Gould, Matthew K., et al.
Publicado: (2014)

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei
por: Cayla, Mathieu, et al.
Publicado: (2020)

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei
por: Rico, Eva, et al.
Publicado: (2013)

High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei
por: MacGregor, Paula, et al.
Publicado: (2014)

Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei
por: Mony, Binny M., et al.
Publicado: (2013)

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F(1)F(o)-ATPase
por: Eze, Anthonius A., et al.
Publicado: (2016)

Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form Trypanosoma brucei Rescues Genetic Knockdown of Mitochondrial Gene Expression
por: Schaffner-Barbero, Claudia, et al.
Publicado: (2018)

Deep kinetoplast genome analyses result in a novel molecular assay for detecting Trypanosoma brucei gambiense-specific minicircles
por: Geerts, Manon, et al.
Publicado: (2022)

Bioenergetic consequences of F(o)F(1)–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei
por: Hierro-Yap, Carolina, et al.
Publicado: (2021)

Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector
por: Dewar, Caroline E., et al.
Publicado: (2022)

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host
por: Capewell, Paul, et al.
Publicado: (2013)

Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections
por: MacGregor, Paula, et al.
Publicado: (2011)

Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1
por: Durrant, Jacob D., et al.
Publicado: (2010)

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms
por: Surve, Sachin V., et al.
Publicado: (2017)

Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity
por: Natesan, Senthil Kumar A., et al.
Publicado: (2011)

Fly transmission and mating of Trypanosoma brucei brucei strain 427
por: Peacock, Lori, et al.
Publicado: (2008)

The F(0)F(1)-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei
por: Zíková, Alena, et al.
Publicado: (2009)

Comment on ‘Unexpected plasticity in the life cycle of Trypanosoma brucei’
por: Matthews, Keith R, et al.
Publicado: (2022)

A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases
por: Zimmermann, Stephan, et al.
Publicado: (2016)

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
por: Steketee, Pieter C., et al.
Publicado: (2021)

Characterization of a highly diverged mitochondrial ATP synthase F(o) subunit in Trypanosoma brucei
por: Dewar, Caroline E., et al.
Publicado: (2022)

Mitochondrial dual-coding genes in Trypanosoma brucei
por: Kirby, Laura E., et al.
Publicado: (2017)

Differential virulence and tsetse fly transmissibility of Trypanosoma congolense and Trypanosoma brucei strains
por: Gitonga, Purity K., et al.
Publicado: (2017)

The SPARC complex defines RNAPII promoters in Trypanosoma brucei
por: Staneva, Desislava P, et al.
Publicado: (2022)

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics
por: MacGregor, Paula, et al.
Publicado: (2010)

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei
por: Dewar, Simon, et al.
Publicado: (2016)

SUMOylation in Trypanosoma brucei
por: Klein, Cornelia Andrea, et al.
Publicado: (2013)

Intraclonal mating occurs during tsetse transmission of Trypanosoma brucei
por: Peacock, Lori, et al.
Publicado: (2009)

Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro
por: Rojas, Federico, et al.
Publicado: (2021)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes
por: Moreno, S Andrea, et al.
Publicado: (2015)

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei
por: de Macêdo, Juan P., et al.
Publicado: (2015)

Molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei
por: Hoffmann, Anneliese, et al.
Publicado: (2018)

Degradation of cyclin B is critical for nuclear division in Trypanosoma brucei
por: Hayashi, Hanako, et al.
Publicado: (2018)

Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei
por: McWilliam, Kirsty R., et al.
Publicado: (2019)

Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi
por: Habila, Nathan, et al.
Publicado: (2010)

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei
por: Walrad, Pegine B., et al.
Publicado: (2012)

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei
por: Käser, Sandro, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_69qc2pcn7u4b980eppk7h5q5lf