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Probing the binding site of novel selective positive allosteric modulators at the M(1) muscarinic acetylcholine receptor

Subtype-selective allosteric modulation of the M(1) muscarinic acetylcholine (ACh) receptor (M(1) mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quinolone carboxylic acid, BQCA, a selective M(1) mAChR positive allosteri...

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Detalles Bibliográficos
Autores principales:	Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066355/ https://www.ncbi.nlm.nih.gov/pubmed/29777683 http://dx.doi.org/10.1016/j.bcp.2018.05.009

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