A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway

Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. interrogans caused apoptosis of p...

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Detalles Bibliográficos
Autores principales: Du, Peng, Li, Shi-Jun, Ojcius, David M., Li, Kai-Xuan, Hu, Wei-Lin, Lin, Xu’ai, Sun, Ai-Hua, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066479/
https://www.ncbi.nlm.nih.gov/pubmed/30061622
http://dx.doi.org/10.1038/s41426-018-0135-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066479/
https://www.ncbi.nlm.nih.gov/pubmed/30061622
http://dx.doi.org/10.1038/s41426-018-0135-9

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