Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation

Located contiguously on the long arm of the second chromosome are gene paralogs encoding the immunoglobulin-family co-activation receptors CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4). CD28 and CTLA4 share the same B7 ligands yet each provides opposing proliferative signals to T cell...

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Detalles Bibliográficos
Autores principales: Le Coz, Carole, Nolan, Brian E., Trofa, Melissa, Kamsheh, Alicia M., Khokha, Mustafa K., Lakhani, Saquib A., Novelli, Antonio, Zackai, Elaine H., Sullivan, Kathleen E., Briuglia, Silvana, Bhatti, Tricia R., Romberg, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066513/
https://www.ncbi.nlm.nih.gov/pubmed/30087679
http://dx.doi.org/10.3389/fimmu.2018.01715

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