Polypharmacology of Berberine Based on Multi-Target Binding Motifs

Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) for polypharmacological drugs, such as berberine. Met...

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Detalles Bibliográficos
Autores principales: Chu, Ming, Chen, Xi, Wang, Jing, Guo, Likai, Wang, Qianqian, Gao, Zirui, Kang, Jiarui, Zhang, Mingbo, Feng, Jinqiu, Guo, Qi, Li, Binghua, Zhang, Chengrui, Guo, Xueyuan, Chu, Zhengyun, Wang, Yuedan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066535/
https://www.ncbi.nlm.nih.gov/pubmed/30087614
http://dx.doi.org/10.3389/fphar.2018.00801

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