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A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening

Background: The fluoropyrimidine anticancer drug, especially 5- fluorouracil (5-FU) and its prodrug capecitabine are still being the backbone of chemotherapeutic regimens for colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) is the crucial enzyme in the catabolism of 5-FU. Over the past 30 ye...

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Detalles Bibliográficos
Autores principales:	Tong, Chi C., Lam, Ching W., Lam, Ka O., Lee, Victor H. F., Luk, Mai-Yee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066555/ https://www.ncbi.nlm.nih.gov/pubmed/30087856 http://dx.doi.org/10.3389/fonc.2018.00279

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