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The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

Human aging is associated with a profound loss of thymus productivity, yet naïve T lymphocytes still maintain their numbers by division in the periphery for many years. The extent of such proliferation may depend on the cytokine environment, including IL-7 and T-cell receptor (TCR) “tonic” signaling...

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Detalles Bibliográficos
Autores principales:	Egorov, Evgeny S., Kasatskaya, Sofya A., Zubov, Vasiliy N., Izraelson, Mark, Nakonechnaya, Tatiana O., Staroverov, Dmitriy B., Angius, Andrea, Cucca, Francesco, Mamedov, Ilgar Z., Rosati, Elisa, Franke, Andre, Shugay, Mikhail, Pogorelyy, Mikhail V., Chudakov, Dmitriy M., Britanova, Olga V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066563/ https://www.ncbi.nlm.nih.gov/pubmed/30087674 http://dx.doi.org/10.3389/fimmu.2018.01618

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