Following Ribosome Footprints to Understand Translation at a Genome Wide Level

Protein translation is a key step in gene expression. The development of Ribosome Profiling has allowed the global analysis of this process at sub-codon resolution. In the last years the method has been applied to several models ranging from bacteria to mammalian cells yielding a surprising amount o...

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Detalles Bibliográficos
Autores principales: Eastman, Guillermo, Smircich, Pablo, Sotelo-Silveira, José R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066590/
https://www.ncbi.nlm.nih.gov/pubmed/30069283
http://dx.doi.org/10.1016/j.csbj.2018.04.001
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author Eastman, Guillermo
Smircich, Pablo
Sotelo-Silveira, José R.
author_facet Eastman, Guillermo
Smircich, Pablo
Sotelo-Silveira, José R.
author_sort Eastman, Guillermo
collection PubMed
description Protein translation is a key step in gene expression. The development of Ribosome Profiling has allowed the global analysis of this process at sub-codon resolution. In the last years the method has been applied to several models ranging from bacteria to mammalian cells yielding a surprising amount of insight on the mechanism and the regulation of translation. In this review we describe the key aspects of the experimental protocol and comment on the main conclusions raised in different models.
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spelling pubmed-60665902018-08-01 Following Ribosome Footprints to Understand Translation at a Genome Wide Level Eastman, Guillermo Smircich, Pablo Sotelo-Silveira, José R. Comput Struct Biotechnol J Review Article Protein translation is a key step in gene expression. The development of Ribosome Profiling has allowed the global analysis of this process at sub-codon resolution. In the last years the method has been applied to several models ranging from bacteria to mammalian cells yielding a surprising amount of insight on the mechanism and the regulation of translation. In this review we describe the key aspects of the experimental protocol and comment on the main conclusions raised in different models. Research Network of Computational and Structural Biotechnology 2018-05-01 /pmc/articles/PMC6066590/ /pubmed/30069283 http://dx.doi.org/10.1016/j.csbj.2018.04.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Eastman, Guillermo
Smircich, Pablo
Sotelo-Silveira, José R.
Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title_full Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title_fullStr Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title_full_unstemmed Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title_short Following Ribosome Footprints to Understand Translation at a Genome Wide Level
title_sort following ribosome footprints to understand translation at a genome wide level
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066590/
https://www.ncbi.nlm.nih.gov/pubmed/30069283
http://dx.doi.org/10.1016/j.csbj.2018.04.001
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