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Hacking CD/DVD/Blu-ray for Biosensing

[Image: see text] The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nanoresolution x-, z-axis, and tilt actuator in a compact size. In addition, th...

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Detalles Bibliográficos
Autores principales: Hwu, Edwin En-Te, Boisen, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066758/
https://www.ncbi.nlm.nih.gov/pubmed/29978699
http://dx.doi.org/10.1021/acssensors.8b00340
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author Hwu, Edwin En-Te
Boisen, Anja
author_facet Hwu, Edwin En-Te
Boisen, Anja
author_sort Hwu, Edwin En-Te
collection PubMed
description [Image: see text] The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nanoresolution x-, z-axis, and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro- and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under nondisclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bioapplications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Hacking low-cost and high-performance OPUs may spread micro- and nanoscale biosensing research from research laboratories to citizen scientists around the globe.
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spelling pubmed-60667582018-08-05 Hacking CD/DVD/Blu-ray for Biosensing Hwu, Edwin En-Te Boisen, Anja ACS Sens [Image: see text] The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nanoresolution x-, z-axis, and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub-angstrom displacement sensing, micro- and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under nondisclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bioapplications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Hacking low-cost and high-performance OPUs may spread micro- and nanoscale biosensing research from research laboratories to citizen scientists around the globe. American Chemical Society 2018-07-06 2018-07-27 /pmc/articles/PMC6066758/ /pubmed/29978699 http://dx.doi.org/10.1021/acssensors.8b00340 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Hwu, Edwin En-Te
Boisen, Anja
Hacking CD/DVD/Blu-ray for Biosensing
title Hacking CD/DVD/Blu-ray for Biosensing
title_full Hacking CD/DVD/Blu-ray for Biosensing
title_fullStr Hacking CD/DVD/Blu-ray for Biosensing
title_full_unstemmed Hacking CD/DVD/Blu-ray for Biosensing
title_short Hacking CD/DVD/Blu-ray for Biosensing
title_sort hacking cd/dvd/blu-ray for biosensing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066758/
https://www.ncbi.nlm.nih.gov/pubmed/29978699
http://dx.doi.org/10.1021/acssensors.8b00340
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