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Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With the Crohn Disease Activity Index
We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn’s disease (CD) activity index (CDAI) in patients with CD. METHODS: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity. RESULTS: In all patients, s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066806/ https://www.ncbi.nlm.nih.gov/pubmed/30083065 http://dx.doi.org/10.1177/1179552218791173 |
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author | Chiba, Toshimi Suzuki, Kazuyuki Matsumoto, Takayuki |
author_facet | Chiba, Toshimi Suzuki, Kazuyuki Matsumoto, Takayuki |
author_sort | Chiba, Toshimi |
collection | PubMed |
description | We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn’s disease (CD) activity index (CDAI) in patients with CD. METHODS: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity. RESULTS: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA. CONCLUSIONS: In patients with CD, plasma amino acids appear to be associated with disease activity. |
format | Online Article Text |
id | pubmed-6066806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-60668062018-08-06 Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With the Crohn Disease Activity Index Chiba, Toshimi Suzuki, Kazuyuki Matsumoto, Takayuki Clin Med Insights Gastroenterol Original Research We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn’s disease (CD) activity index (CDAI) in patients with CD. METHODS: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity. RESULTS: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA. CONCLUSIONS: In patients with CD, plasma amino acids appear to be associated with disease activity. SAGE Publications 2018-07-30 /pmc/articles/PMC6066806/ /pubmed/30083065 http://dx.doi.org/10.1177/1179552218791173 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Chiba, Toshimi Suzuki, Kazuyuki Matsumoto, Takayuki Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With the Crohn Disease Activity Index |
title | Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With
the Crohn Disease Activity Index |
title_full | Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With
the Crohn Disease Activity Index |
title_fullStr | Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With
the Crohn Disease Activity Index |
title_full_unstemmed | Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With
the Crohn Disease Activity Index |
title_short | Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With
the Crohn Disease Activity Index |
title_sort | plasma-free amino acid profiles in crohn’s disease: relationship with
the crohn disease activity index |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066806/ https://www.ncbi.nlm.nih.gov/pubmed/30083065 http://dx.doi.org/10.1177/1179552218791173 |
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