DNA Topoisomerase I differentially modulates R-loops across the human genome

BACKGROUND: Co-transcriptional R-loops are abundant non-B DNA structures in mammalian genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing to its ability to resolve both positive and negative supercoils. How Top1 regulates R-loop structures at a global level is unk...

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Detalles Bibliográficos
Autores principales: Manzo, Stefano G., Hartono, Stella R., Sanz, Lionel A., Marinello, Jessica, De Biasi, Sara, Cossarizza, Andrea, Capranico, Giovanni, Chedin, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066927/
https://www.ncbi.nlm.nih.gov/pubmed/30060749
http://dx.doi.org/10.1186/s13059-018-1478-1

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