Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase the intracellular cAMP activities, which...

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Detalles Bibliográficos
Autores principales: Xu, Ying, Zhu, Naping, Xu, Wen, Ye, Han, Liu, Kaiping, Wu, Feiyan, Zhang, Meixi, Ding, Yun, Zhang, Chong, Zhang, Hanting, O'Donnell, James, Pan, Jiangchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066959/
https://www.ncbi.nlm.nih.gov/pubmed/30087608
http://dx.doi.org/10.3389/fnagi.2018.00204

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