Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1

SAMHD1 is a dNTP triphosphohydrolase (dNTPase) that impairs retroviral replication in a subset of noncycling immune cells. Here we show that SAMHD1 is a redox-sensitive enzyme and identify three redox-active cysteines within the protein: C341, C350, and C522. The three cysteines reside near one anot...

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Detalles Bibliográficos
Autores principales: Wang, Zhonghua, Bhattacharya, Akash, White, Tommy, Buffone, Cindy, McCabe, Aine, Nguyen, Laura A., Shepard, Caitlin N., Pardo, Sammy, Kim, Baek, Weintraub, Susan T., Demeler, Borries, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067006/
https://www.ncbi.nlm.nih.gov/pubmed/30044979
http://dx.doi.org/10.1016/j.celrep.2018.06.090

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