Cargando…

Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder

Major depressive disorder (MDD) and bipolar disorder (BD) are common severe affective diseases. Although previous neuroimaging studies have investigated brain abnormalities in MDD or BD, the structural and functional differences between these two disorders remain unclear. In this study, we adopted a...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Lixiang, Wang, Ying, Niu, Chen, Zhong, Shuming, Hu, Huiqing, Chen, Ping, Zhang, Shufei, Chen, Guanmao, Deng, Feng, Lai, Sunkai, Wang, Junjing, Huang, Li, Huang, Ruiwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067086/
https://www.ncbi.nlm.nih.gov/pubmed/30069426
http://dx.doi.org/10.1016/j.nicl.2018.07.002
_version_ 1783343089750900736
author Chen, Lixiang
Wang, Ying
Niu, Chen
Zhong, Shuming
Hu, Huiqing
Chen, Ping
Zhang, Shufei
Chen, Guanmao
Deng, Feng
Lai, Sunkai
Wang, Junjing
Huang, Li
Huang, Ruiwang
author_facet Chen, Lixiang
Wang, Ying
Niu, Chen
Zhong, Shuming
Hu, Huiqing
Chen, Ping
Zhang, Shufei
Chen, Guanmao
Deng, Feng
Lai, Sunkai
Wang, Junjing
Huang, Li
Huang, Ruiwang
author_sort Chen, Lixiang
collection PubMed
description Major depressive disorder (MDD) and bipolar disorder (BD) are common severe affective diseases. Although previous neuroimaging studies have investigated brain abnormalities in MDD or BD, the structural and functional differences between these two disorders remain unclear. In this study, we adopted a multimodal approach, combining voxel-based morphometry (VBM) and functional connectivity (FC), to study the common and distinct structural and functional alterations in unmedicated MDD and BD patients. The VBM analysis revealed that both the MDD and BD patients showed decreased gray matter volume (GMV) in the left anterior cingulate cortex (ACC_L) and right hippocampus (HIP_R) compared with the healthy controls, and the MDD patients showed decreased GMV in the left superior frontal gyrus (SFG_L) and ACC_L compared with the BD patients. Furthermore, we took these clusters as seed regions to analyze the abnormal resting-state functional connectivity (RSFC) in the patients. We found that both the MDD and BD groups had decreased RSFC between the ACC_L and the left orbitofrontal cortex (OFC_L) and that the MDD group had decreased RSFC between the SFG_L and the HIP_L, compared with the healthy controls. Our results revealed that the MDD and BD patients were more similar than different in GMV and RSFC. These findings indicate that investigating the frontal-limbic system could be useful for understanding the underlying mechanisms of these two disorders.
format Online
Article
Text
id pubmed-6067086
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-60670862018-08-01 Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder Chen, Lixiang Wang, Ying Niu, Chen Zhong, Shuming Hu, Huiqing Chen, Ping Zhang, Shufei Chen, Guanmao Deng, Feng Lai, Sunkai Wang, Junjing Huang, Li Huang, Ruiwang Neuroimage Clin Regular Article Major depressive disorder (MDD) and bipolar disorder (BD) are common severe affective diseases. Although previous neuroimaging studies have investigated brain abnormalities in MDD or BD, the structural and functional differences between these two disorders remain unclear. In this study, we adopted a multimodal approach, combining voxel-based morphometry (VBM) and functional connectivity (FC), to study the common and distinct structural and functional alterations in unmedicated MDD and BD patients. The VBM analysis revealed that both the MDD and BD patients showed decreased gray matter volume (GMV) in the left anterior cingulate cortex (ACC_L) and right hippocampus (HIP_R) compared with the healthy controls, and the MDD patients showed decreased GMV in the left superior frontal gyrus (SFG_L) and ACC_L compared with the BD patients. Furthermore, we took these clusters as seed regions to analyze the abnormal resting-state functional connectivity (RSFC) in the patients. We found that both the MDD and BD groups had decreased RSFC between the ACC_L and the left orbitofrontal cortex (OFC_L) and that the MDD group had decreased RSFC between the SFG_L and the HIP_L, compared with the healthy controls. Our results revealed that the MDD and BD patients were more similar than different in GMV and RSFC. These findings indicate that investigating the frontal-limbic system could be useful for understanding the underlying mechanisms of these two disorders. Elsevier 2018-07-06 /pmc/articles/PMC6067086/ /pubmed/30069426 http://dx.doi.org/10.1016/j.nicl.2018.07.002 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Chen, Lixiang
Wang, Ying
Niu, Chen
Zhong, Shuming
Hu, Huiqing
Chen, Ping
Zhang, Shufei
Chen, Guanmao
Deng, Feng
Lai, Sunkai
Wang, Junjing
Huang, Li
Huang, Ruiwang
Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title_full Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title_fullStr Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title_full_unstemmed Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title_short Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
title_sort common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067086/
https://www.ncbi.nlm.nih.gov/pubmed/30069426
http://dx.doi.org/10.1016/j.nicl.2018.07.002
work_keys_str_mv AT chenlixiang commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT wangying commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT niuchen commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT zhongshuming commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT huhuiqing commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT chenping commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT zhangshufei commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT chenguanmao commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT dengfeng commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT laisunkai commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT wangjunjing commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT huangli commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder
AT huangruiwang commonanddistinctabnormalfrontallimbicsystemstructuralandfunctionalpatternsinpatientswithmajordepressionandbipolardisorder