Disruption of GRIN2B Impairs Differentiation in Human Neurons

Heterozygous loss-of-function mutations in GRIN2B, a subunit of the NMDA receptor, cause intellectual disability and language impairment. We developed clonal models of GRIN2B deletion and loss-of-function mutations in a region coding for the glutamate binding domain in human cells and generated neur...

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Detalles Bibliográficos
Autores principales: Bell, Scott, Maussion, Gilles, Jefri, Malvin, Peng, Huashan, Theroux, Jean-Francois, Silveira, Heika, Soubannier, Vincent, Wu, Hanrong, Hu, Peng, Galat, Ekaterina, Torres-Platas, S. Gabriela, Boudreau-Pinsonneault, Camille, O'Leary, Liam A., Galat, Vasiliy, Turecki, Gustavo, Durcan, Thomas M., Fon, Edward A., Mechawar, Naguib, Ernst, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067152/
https://www.ncbi.nlm.nih.gov/pubmed/29937144
http://dx.doi.org/10.1016/j.stemcr.2018.05.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067152/
https://www.ncbi.nlm.nih.gov/pubmed/29937144
http://dx.doi.org/10.1016/j.stemcr.2018.05.018

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