Cargando…

Disruption of GRIN2B Impairs Differentiation in Human Neurons

Heterozygous loss-of-function mutations in GRIN2B, a subunit of the NMDA receptor, cause intellectual disability and language impairment. We developed clonal models of GRIN2B deletion and loss-of-function mutations in a region coding for the glutamate binding domain in human cells and generated neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bell, Scott, Maussion, Gilles, Jefri, Malvin, Peng, Huashan, Theroux, Jean-Francois, Silveira, Heika, Soubannier, Vincent, Wu, Hanrong, Hu, Peng, Galat, Ekaterina, Torres-Platas, S. Gabriela, Boudreau-Pinsonneault, Camille, O'Leary, Liam A., Galat, Vasiliy, Turecki, Gustavo, Durcan, Thomas M., Fon, Edward A., Mechawar, Naguib, Ernst, Carl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067152/ https://www.ncbi.nlm.nih.gov/pubmed/29937144 http://dx.doi.org/10.1016/j.stemcr.2018.05.018

Ejemplares similares

Stimulation of L‐type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells
por: Jefri, Malvin, et al.
Publicado: (2020)

FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells
por: Hettige, Nuwan C., et al.
Publicado: (2022)

Down syndrome iPSC model: endothelial perspective on tumor development
por: Perepitchka, Mariana, et al.
Publicado: (2020)

Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide
por: Nagy, Corina, et al.
Publicado: (2016)

iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome
por: Galat, Yekaterina, et al.
Publicado: (2020)

Regulation of a Truncated Form of Tropomyosin-Related Kinase B (TrkB) by Hsa-miR-185* in Frontal Cortex of Suicide Completers
por: Maussion, Gilles, et al.
Publicado: (2012)

Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells
por: Bell, Scott, et al.
Publicado: (2021)

Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
por: O'Leary, Liam Anuj, et al.
Publicado: (2021)

Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential
por: Galat, Yekaterina, et al.
Publicado: (2017)

NK cell-based cancer immunotherapy: from basic biology to clinical development
por: Liu, Sizhe, et al.
Publicado: (2021)

Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
por: Galat, Vasiliy, et al.
Publicado: (2016)

Lysine Deprivation during Maternal Consumption of Low-Protein Diets Could Adversely Affect Early Embryo Development and Health in Adulthood
por: Van Winkle, Lon J., et al.
Publicado: (2020)

Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum
por: Vaillancourt, Kathryn, et al.
Publicado: (2021)

Characterization of Vimentin-Immunoreactive Astrocytes in the Human Brain
por: O’Leary, Liam Anuj, et al.
Publicado: (2020)

Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide
por: Devorak, Julia, et al.
Publicado: (2015)

Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety: A Parallel Analysis of a Randomized Controlled Trial
por: Belliveau, Claudia, et al.
Publicado: (2021)

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
por: Galat, Andrzej
Publicado: (2017)

Introduction to Peptidyl-Prolyl cis/trans Isomerase (PPIase) Series †
por: Galat, Andrzej
Publicado: (2019)

Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase)
por: Galat, Andrzej
Publicado: (2019)

Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine
por: Chen, Gary G., et al.
Publicado: (2017)

Morphometric characterization of microglial phenotypes in human cerebral cortex
por: Torres-Platas, Susana G, et al.
Publicado: (2014)

Age and Haplotype Variations within FADS1 Interact and Associate with Alterations in Fatty Acid Composition in Human Male Cortical Brain Tissue
por: Freemantle, Erika, et al.
Publicado: (2012)

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment
por: Galat, Yekaterina, et al.
Publicado: (2021)

In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies
por: Galat, Yekaterina, et al.
Publicado: (2023)

miR-1202: A Primate Specific and Brain Enriched miRNA Involved in Major Depression and Antidepressant Treatment
por: Lopez, Juan Pablo, et al.
Publicado: (2014)

Use of the SIGN IM nail system to stabilize tibiotalocalcaneal arthrodesis in two African hospital settings
por: Burke, Sydney E., et al.
Publicado: (2020)

ONC201-Induced Mitochondrial Dysfunction, Senescence-like Phenotype, and Sensitization of Cultured BT474 Human Breast Cancer Cells to TRAIL
por: Mishukov, Artem, et al.
Publicado: (2022)

Distinct roles of GRIN2A and GRIN2B variants in neurological conditions
por: Myers, Scott J, et al.
Publicado: (2019)

Assessment of NMDA receptor genes (GRIN2A, GRIN2B and GRIN2C) as candidate genes in the development of degenerative lumbar scoliosis
por: KIM, KI-TACK, et al.
Publicado: (2013)

Study of Early Onset Schizophrenia: Associations of GRIN2A and GRIN2B Polymorphisms
por: Poltavskaya, Evgeniya G., et al.
Publicado: (2021)

Serological Evidence for Influenza A Viruses Among Domestic Dogs and Cats in Kyiv, Ukraine
por: Kovalenko, Ganna, et al.
Publicado: (2021)

Isolation of Oct4-Expressing Extraembryonic Endoderm Precursor Cell Lines
por: Debeb, Bisrat G., et al.
Publicado: (2009)

Global and Site-Specific Changes in 5-Methylcytosine and 5-Hydroxymethylcytosine after Extended Post-mortem Interval
por: Gross, Jeffrey A., et al.
Publicado: (2016)

Association of genetic variants of GRIN2B with autism
por: Pan, Yongcheng, et al.
Publicado: (2015)

Selected single-nucleotide variants in GRIN1, GRIN2A, and GRIN2B encoding subunits of the NMDA receptor are not biomarkers of schizophrenia resistant to clozapine: exploratory study
por: Krzystanek, Marek, et al.
Publicado: (2020)

Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides
por: Maheu, Marissa E., et al.
Publicado: (2015)

Threonine appears to be essential for proliferation of human as well as mouse embryonic stem cells
por: Van Winkle, Lon J., et al.
Publicado: (2014)

Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure
por: Fan, Dihan, et al.
Publicado: (2021)

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription
por: Werner, Michael S., et al.
Publicado: (2017)

A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing
por: Bell, Scott, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r8fpkdt9l56r198bl51ja003a4