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Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely unexplored. A rat model of pressure-loaded heart is developed by trans-aortic constriction (TAC)...

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Detalles Bibliográficos
Autores principales:	Ye, Lei, Su, Liping, Wang, Chenxu, Loo, Szejie, Tee, Guizhen, Tan, Shihua, Khin, Sandar Win, Ko, Shijie, Su, Boyang, Cook, Stuart A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067738/ https://www.ncbi.nlm.nih.gov/pubmed/30063764 http://dx.doi.org/10.1371/journal.pone.0201498

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