Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria

The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the myxobacterium Archangium gephyra that inhibits growth of transformed mammalian cel...

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Detalles Bibliográficos
Autores principales: Muthukumar, Yazh, Münkemer, Johanna, Mathieu, Daniel, Richter, Christian, Schwalbe, Harald, Steinmetz, Heinrich, Kessler, Wolfgang, Reichelt, Joachim, Beutling, Ulrike, Frank, Ronald, Büssow, Konrad, van den Heuvel, Joop, Brönstrup, Mark, Taylor, Richard E., Laschat, Sabine, Sasse, Florenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067752/
https://www.ncbi.nlm.nih.gov/pubmed/30063768
http://dx.doi.org/10.1371/journal.pone.0201605

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