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Noninvasive vaccination against infectious diseases

The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models...

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Autores principales: Zheng, Zhichao, Diaz-Arévalo, Diana, Guan, Hongbing, Zeng, Mingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067898/
https://www.ncbi.nlm.nih.gov/pubmed/29624470
http://dx.doi.org/10.1080/21645515.2018.1461296
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author Zheng, Zhichao
Diaz-Arévalo, Diana
Guan, Hongbing
Zeng, Mingtao
author_facet Zheng, Zhichao
Diaz-Arévalo, Diana
Guan, Hongbing
Zeng, Mingtao
author_sort Zheng, Zhichao
collection PubMed
description The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future.
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spelling pubmed-60678982018-08-06 Noninvasive vaccination against infectious diseases Zheng, Zhichao Diaz-Arévalo, Diana Guan, Hongbing Zeng, Mingtao Hum Vaccin Immunother Reviews The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future. Taylor & Francis 2018-05-17 /pmc/articles/PMC6067898/ /pubmed/29624470 http://dx.doi.org/10.1080/21645515.2018.1461296 Text en © 2018 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Reviews
Zheng, Zhichao
Diaz-Arévalo, Diana
Guan, Hongbing
Zeng, Mingtao
Noninvasive vaccination against infectious diseases
title Noninvasive vaccination against infectious diseases
title_full Noninvasive vaccination against infectious diseases
title_fullStr Noninvasive vaccination against infectious diseases
title_full_unstemmed Noninvasive vaccination against infectious diseases
title_short Noninvasive vaccination against infectious diseases
title_sort noninvasive vaccination against infectious diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067898/
https://www.ncbi.nlm.nih.gov/pubmed/29624470
http://dx.doi.org/10.1080/21645515.2018.1461296
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