Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms

The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avoidance of factor VIII exposure during innate immun...

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Detalles Bibliográficos
Autores principales: Georgescu, Maria T., Moorehead, Paul C., van Velzen, Alice S., Nesbitt, Kate, Reipert, Birgit M., Steinitz, Katharina N., Schuster, Maria, Hough, Christine, Lillicrap, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068046/
https://www.ncbi.nlm.nih.gov/pubmed/29674503
http://dx.doi.org/10.3324/haematol.2018.189852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068046/
https://www.ncbi.nlm.nih.gov/pubmed/29674503
http://dx.doi.org/10.3324/haematol.2018.189852

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