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Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avoidance of factor VIII exposure during innate immun...
Autores principales: | Georgescu, Maria T., Moorehead, Paul C., van Velzen, Alice S., Nesbitt, Kate, Reipert, Birgit M., Steinitz, Katharina N., Schuster, Maria, Hough, Christine, Lillicrap, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068046/ https://www.ncbi.nlm.nih.gov/pubmed/29674503 http://dx.doi.org/10.3324/haematol.2018.189852 |
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