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The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI

The article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse c...

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Autores principales: Kjøllesdal, Marte K. R., Smith, George Davey, Ariansen, Inger, Kinge, Jonas Minet, Degerud, Eirik, Næss, Øyvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068135/
https://www.ncbi.nlm.nih.gov/pubmed/30065250
http://dx.doi.org/10.1038/s41598-018-29089-z
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author Kjøllesdal, Marte K. R.
Smith, George Davey
Ariansen, Inger
Kinge, Jonas Minet
Degerud, Eirik
Næss, Øyvind
author_facet Kjøllesdal, Marte K. R.
Smith, George Davey
Ariansen, Inger
Kinge, Jonas Minet
Degerud, Eirik
Næss, Øyvind
author_sort Kjøllesdal, Marte K. R.
collection PubMed
description The article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from Norwegian health surveys (1974–2003) (midlife BMI, smoking, blood pressure, total cholesterol, heart rate), Military Conscription Records, National Tuberculosis Screenings (early adulthood BMI), National Educational Registry and Cause of Death Registry were linked. Participants with data on BMI in early adulthood and midlife were included (n = 148.886). Hazard Ratio (HR) for CVD mortality was higher in men with midlife obesity relative to normal weight (HR = 1.46(95% CI 1.25, 1.70). For all-cause mortality, HR was higher in those with obesity or underweight in midlife relative to normal weight (Men:HR = 1.19(95% CI 1.09, 1.29), HR = 2.49(95% CI 1.81, 3.43) Women:HR = 1.33(95% CI 1.13, 1.56), HR = 1.61(95% CI 1.22, 2.13)). In instrumental variable analyses, increased BMI became more strongly associated with CVD and all-cause mortality, and the increased risk of all-cause mortality among the underweight attenuated.
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spelling pubmed-60681352018-08-03 The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI Kjøllesdal, Marte K. R. Smith, George Davey Ariansen, Inger Kinge, Jonas Minet Degerud, Eirik Næss, Øyvind Sci Rep Article The article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from Norwegian health surveys (1974–2003) (midlife BMI, smoking, blood pressure, total cholesterol, heart rate), Military Conscription Records, National Tuberculosis Screenings (early adulthood BMI), National Educational Registry and Cause of Death Registry were linked. Participants with data on BMI in early adulthood and midlife were included (n = 148.886). Hazard Ratio (HR) for CVD mortality was higher in men with midlife obesity relative to normal weight (HR = 1.46(95% CI 1.25, 1.70). For all-cause mortality, HR was higher in those with obesity or underweight in midlife relative to normal weight (Men:HR = 1.19(95% CI 1.09, 1.29), HR = 2.49(95% CI 1.81, 3.43) Women:HR = 1.33(95% CI 1.13, 1.56), HR = 1.61(95% CI 1.22, 2.13)). In instrumental variable analyses, increased BMI became more strongly associated with CVD and all-cause mortality, and the increased risk of all-cause mortality among the underweight attenuated. Nature Publishing Group UK 2018-07-31 /pmc/articles/PMC6068135/ /pubmed/30065250 http://dx.doi.org/10.1038/s41598-018-29089-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kjøllesdal, Marte K. R.
Smith, George Davey
Ariansen, Inger
Kinge, Jonas Minet
Degerud, Eirik
Næss, Øyvind
The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title_full The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title_fullStr The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title_full_unstemmed The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title_short The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
title_sort association between bmi and mortality using early adulthood bmi as an instrumental variable for midlife bmi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068135/
https://www.ncbi.nlm.nih.gov/pubmed/30065250
http://dx.doi.org/10.1038/s41598-018-29089-z
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