Systems analysis of intracellular pH vulnerabilities for cancer therapy

A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of extracellular acidosis are known, the roles of intracellular alkalization are incompletely understood. By reconstructing and integrating enzymatic pH-d...

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Detalles Bibliográficos
Autores principales: Persi, Erez, Duran-Frigola, Miquel, Damaghi, Mehdi, Roush, William R., Aloy, Patrick, Cleveland, John L., Gillies, Robert J., Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068141/
https://www.ncbi.nlm.nih.gov/pubmed/30065243
http://dx.doi.org/10.1038/s41467-018-05261-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068141/
https://www.ncbi.nlm.nih.gov/pubmed/30065243
http://dx.doi.org/10.1038/s41467-018-05261-x

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