Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the Apc(Min/+) mouse model, tumor spheroid cultures, and patient-derived orthoxenografts to address this divergent ligand-dependent Notch fu...

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Detalles Bibliográficos
Autores principales: López-Arribillaga, Erika, Rodilla, Verónica, Colomer, Carlota, Vert, Anna, Shelton, Amy, Cheng, Jason H., Yan, Bing, Gonzalez-Perez, Abel, Junttila, Melissa R., Iglesias, Mar, Torres, Ferran, Albanell, Joan, Villanueva, Alberto, Bigas, Anna, Siebel, Christian W., Espinosa, LLuís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068201/
https://www.ncbi.nlm.nih.gov/pubmed/30065304
http://dx.doi.org/10.1038/s41467-018-05385-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068201/
https://www.ncbi.nlm.nih.gov/pubmed/30065304
http://dx.doi.org/10.1038/s41467-018-05385-0

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