Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

KEY POINTS: The cardiac metabolic reprogramming seen in heart diseases such as myocardial infarction and hypertrophy shares similarities with that seen in chronic hypoxia, but understanding of how the hypoxic heart responds to further hypoxic challenge – hypoxic tolerance – is limited. The pyruvate...

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Detalles Bibliográficos
Autores principales: Handzlik, Michal K., Constantin‐Teodosiu, Dumitru, Greenhaff, Paul L., Cole, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068244/
https://www.ncbi.nlm.nih.gov/pubmed/29383727
http://dx.doi.org/10.1113/JP275357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068244/
https://www.ncbi.nlm.nih.gov/pubmed/29383727
http://dx.doi.org/10.1113/JP275357

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