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Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4(+) Treg in nonhuman primates
Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4(+) tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4(+) Treg depletion. We have demonstrated that up to a 90% depletion was achieved and the deple...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068354/ https://www.ncbi.nlm.nih.gov/pubmed/29873181 http://dx.doi.org/10.1002/1878-0261.12331 |