Cargando…

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4(+) Treg in nonhuman primates

Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4(+) tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4(+) Treg depletion. We have demonstrated that up to a 90% depletion was achieved and the deple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhaohui, Louras, Nathan J., Lellouch, Alexandre G., Pratts, Shannon G., Zhang, Huiping, Wang, Haoyu, Huang, Christene A., Cetrulo, Curtis L., Madsen, Joren C., Sachs, David H., Wang, Zhirui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068354/ https://www.ncbi.nlm.nih.gov/pubmed/29873181 http://dx.doi.org/10.1002/1878-0261.12331

Ejemplares similares

Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
por: Wang, Haoyu, et al.
Publicado: (2020)

Diphtheria toxin‐based anti‐human CD19 immunotoxin for targeting human CD19(+) tumors
por: Zheng, Qian, et al.
Publicado: (2017)

CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model
por: Wang, Zhaohui, et al.
Publicado: (2023)

CD4(+)CCR8(+) Tregs in ovarian cancer: a potential effector Tregs for immune regulation
por: Liu, Shuna, et al.
Publicado: (2023)

Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma
por: Ono, Shoya, et al.
Publicado: (2022)

Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates
por: Murray, Jason, et al.
Publicado: (2023)

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10
por: Lim, Herman D., et al.
Publicado: (2021)

Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4(+)CCR6(+ )Th/Treg cell subset imbalance in ankylosing spondylitis
por: Wu, Yanfeng, et al.
Publicado: (2011)

CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients
por: Andalib, Alireza, et al.
Publicado: (2013)

Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth
por: Domingueti, Catherine-Bueno, et al.
Publicado: (2019)

Role of the Chemokine Receptors CCR1, CCR2 and CCR4 in the Pathogenesis of Experimental Dengue Infection in Mice
por: Guabiraba, Rodrigo, et al.
Publicado: (2010)

Building on the Ccr4‐Not architecture
por: Villanyi, Zoltan, et al.
Publicado: (2016)

Reduced CCR6(+)IL-17A(+)Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A(+)Treg Cells in Lungs of Patients With Allergic Asthma
por: Shen, Xiaokun, et al.
Publicado: (2021)

Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus
por: D’Souza, Saritha S., et al.
Publicado: (2022)

CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation
por: Kim, Jong Youl, et al.
Publicado: (2022)

IL-35 promotes CD4(+)Foxp3(+) Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms
por: Shao, Ying, et al.
Publicado: (2021)

57 Increased Frequency of CD4+ CCR4+ CCR9+ Cells in Patients With Allergic Conjunctivitis
por: Alonso-Sánchez, Miguel E., et al.
Publicado: (2012)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4
por: Korbecki, Jan, et al.
Publicado: (2020)

Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP
por: Yamano, Yoshihisa, et al.
Publicado: (2015)

Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs
por: Ferhat, Maroua, et al.
Publicado: (2021)

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence
por: Mittal, Saloni, et al.
Publicado: (2011)

131 Expression of Chemokine Receptors CCR1, CCR3, CCR4, CCR5, CCR8 and CXCR3 in Human Nasal Polyps (NP); Comparison With NP From Allergic Patients With Aspirin Intolerance
por: Fundova, Petra, et al.
Publicado: (2012)

The Regulatory Properties of the Ccr4–Not Complex
por: Chalabi Hagkarim, Nafiseh, et al.
Publicado: (2020)

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4–Not nuclease module
por: Maryati, Maryati, et al.
Publicado: (2015)

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance
por: Li, Yu, et al.
Publicado: (2023)

Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma
por: Fujii, Keiichiro, et al.
Publicado: (2020)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands
por: Korbecki, Jan, et al.
Publicado: (2020)

Efficient Redirection of NK Cells by Genetic Modification with Chemokine Receptors CCR4 and CCR2B
por: Feigl, Frederik Fabian, et al.
Publicado: (2023)

Insights into the structure and architecture of the CCR4–NOT complex
por: Xu, Kun, et al.
Publicado: (2014)

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
por: Ukleja, Marta, et al.
Publicado: (2016)

CCR4 drives ATLL jail break
por: Shannon, Kevin M.
Publicado: (2014)

Tocilizumab monotherapy uncovered the role of the CCL22/17‐CCR4(+) Treg axis during remission of crescentic glomerulonephritis
por: Sakai, Ryota, et al.
Publicado: (2020)

Skewed Lung CCR4 to CCR6 CD4(+) T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function
por: Adegunsoye, Ayodeji, et al.
Publicado: (2016)

Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas
por: Kitadate, Akihiro, et al.
Publicado: (2018)

The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7
por: Hayasaka, Haruko, et al.
Publicado: (2015)

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive αβT Cells in the Adult Thymus
por: Cowan, Jennifer E., et al.
Publicado: (2014)

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets
por: Buskermolen, Jeroen K., et al.
Publicado: (2017)

CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
por: Chang, Xiao L., et al.
Publicado: (2021)

Alternative splicing of CNOT7 diversifies CCR4–NOT functions
por: Chapat, Clément, et al.
Publicado: (2017)

FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer
por: Sarkar, Tania, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uje8q1pfbr6i5clpdgvkhkpg1u