ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report

Intradural extramedullary spinal cord metastases in lung cancer are rarely reported, but are a disastrous event because of severe clinical symptoms and poor prognosis. Herein, we report a case of a lung cancer patient with ALK rearrangement who experienced brain, leptomeningeal, and intradural extra...

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Autores principales: Xu, Yan, Zhong, Wei, Chen, Minjiang, Zhao, Jing, Wang, Mengzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068429/
https://www.ncbi.nlm.nih.gov/pubmed/29862659
http://dx.doi.org/10.1111/1759-7714.12778
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author Xu, Yan
Zhong, Wei
Chen, Minjiang
Zhao, Jing
Wang, Mengzhao
author_facet Xu, Yan
Zhong, Wei
Chen, Minjiang
Zhao, Jing
Wang, Mengzhao
author_sort Xu, Yan
collection PubMed
description Intradural extramedullary spinal cord metastases in lung cancer are rarely reported, but are a disastrous event because of severe clinical symptoms and poor prognosis. Herein, we report a case of a lung cancer patient with ALK rearrangement who experienced brain, leptomeningeal, and intradural extramedullary spinal cord metastases after developing resistance to crizotinib. After ceritinib therapy, his clinical symptoms improved and magnetic resonance imaging revealed that the intradural extramedullary lesions had reduced.
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spelling pubmed-60684292018-08-03 ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report Xu, Yan Zhong, Wei Chen, Minjiang Zhao, Jing Wang, Mengzhao Thorac Cancer Case Reports Intradural extramedullary spinal cord metastases in lung cancer are rarely reported, but are a disastrous event because of severe clinical symptoms and poor prognosis. Herein, we report a case of a lung cancer patient with ALK rearrangement who experienced brain, leptomeningeal, and intradural extramedullary spinal cord metastases after developing resistance to crizotinib. After ceritinib therapy, his clinical symptoms improved and magnetic resonance imaging revealed that the intradural extramedullary lesions had reduced. John Wiley & Sons Australia, Ltd 2018-06-04 2018-08 /pmc/articles/PMC6068429/ /pubmed/29862659 http://dx.doi.org/10.1111/1759-7714.12778 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Xu, Yan
Zhong, Wei
Chen, Minjiang
Zhao, Jing
Wang, Mengzhao
ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title_full ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title_fullStr ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title_full_unstemmed ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title_short ALK‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
title_sort alk‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068429/
https://www.ncbi.nlm.nih.gov/pubmed/29862659
http://dx.doi.org/10.1111/1759-7714.12778
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