Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

Polycystic kidney disease (PKD) and other renal ciliopathies are characterized by cysts, inflammation, and fibrosis. Cilia function as signaling centers, but a molecular link to inflammation in the kidney has not been established. Here, we show that cilia in renal epithelia activate chemokine signal...

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Detalles Bibliográficos
Autores principales: Viau, Amandine, Bienaimé, Frank, Lukas, Kamile, Todkar, Abhijeet P, Knoll, Manuel, Yakulov, Toma A, Hofherr, Alexis, Kretz, Oliver, Helmstädter, Martin, Reichardt, Wilfried, Braeg, Simone, Aschman, Tom, Merkle, Annette, Pfeifer, Dietmar, Dumit, Verónica I, Gubler, Marie‐Claire, Nitschke, Roland, Huber, Tobias B, Terzi, Fabiola, Dengjel, Jörn, Grahammer, Florian, Köttgen, Michael, Busch, Hauke, Boerries, Melanie, Walz, Gerd, Triantafyllopoulou, Antigoni, Kuehn, E Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068446/
https://www.ncbi.nlm.nih.gov/pubmed/29925518
http://dx.doi.org/10.15252/embj.201798615

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