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In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster

Introduction: The top priority for active immunoprophylaxis of pertussis is the immunisation of infants as they can sometimes develop severe multiple-organ complications. Objectives: The aim of the work is the identification of factors negatively affecting vaccine immunity to pertussis in preschool...

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Autores principales: Bednarek, Anna, Bodajko-Grochowska, Anna, Hasiec, Barbara, Klepacz, Robert, Szczekala, Katarzyna, Zarzycka, Danuta, Emeryk, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068489/
https://www.ncbi.nlm.nih.gov/pubmed/29986481
http://dx.doi.org/10.3390/ijerph15071432
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author Bednarek, Anna
Bodajko-Grochowska, Anna
Hasiec, Barbara
Klepacz, Robert
Szczekala, Katarzyna
Zarzycka, Danuta
Emeryk, Andrzej
author_facet Bednarek, Anna
Bodajko-Grochowska, Anna
Hasiec, Barbara
Klepacz, Robert
Szczekala, Katarzyna
Zarzycka, Danuta
Emeryk, Andrzej
author_sort Bednarek, Anna
collection PubMed
description Introduction: The top priority for active immunoprophylaxis of pertussis is the immunisation of infants as they can sometimes develop severe multiple-organ complications. Objectives: The aim of the work is the identification of factors negatively affecting vaccine immunity to pertussis in preschool children prior to the administration of the first booster. Patients and Methods: The research was conducted on 352 children from 4.5 to 5.9 years of age who were hospitalised in the University Children’s Hospital in Lublin (Poland) from 1 January 2012 to 31 December 2015. The children taking part in the study had been administered all the mandatory vaccines from their birth to the age of 2 or 2.5 years old according to the Polish Immunisation Program 2008–2009. The immunoenzymatic method ELISA (enzyme-linked immunosorbent assay) was applied to assess vaccine immunity to tetanus, diphtheria, pertussis, Haemophilus influenzae type b (Hib), poliomyelitis (IPV), mumps, rubella and measles. The level of vaccine antibodies to hepatitis type B was determined chemilumiscently. Results: The protective antibody titre was not found in 41 (11.65%) children before the administration of the booster. To verify the collective impact of parameters analysed on antibody titre to pertussis, the Generalized Linear Model (GLZ) was used. Gender, type of vaccine, asthma, Hib and mumps antibody titres have been shown to be predictors of vaccine immunity to pertussis. Conclusions: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations.
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spelling pubmed-60684892018-08-07 In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster Bednarek, Anna Bodajko-Grochowska, Anna Hasiec, Barbara Klepacz, Robert Szczekala, Katarzyna Zarzycka, Danuta Emeryk, Andrzej Int J Environ Res Public Health Article Introduction: The top priority for active immunoprophylaxis of pertussis is the immunisation of infants as they can sometimes develop severe multiple-organ complications. Objectives: The aim of the work is the identification of factors negatively affecting vaccine immunity to pertussis in preschool children prior to the administration of the first booster. Patients and Methods: The research was conducted on 352 children from 4.5 to 5.9 years of age who were hospitalised in the University Children’s Hospital in Lublin (Poland) from 1 January 2012 to 31 December 2015. The children taking part in the study had been administered all the mandatory vaccines from their birth to the age of 2 or 2.5 years old according to the Polish Immunisation Program 2008–2009. The immunoenzymatic method ELISA (enzyme-linked immunosorbent assay) was applied to assess vaccine immunity to tetanus, diphtheria, pertussis, Haemophilus influenzae type b (Hib), poliomyelitis (IPV), mumps, rubella and measles. The level of vaccine antibodies to hepatitis type B was determined chemilumiscently. Results: The protective antibody titre was not found in 41 (11.65%) children before the administration of the booster. To verify the collective impact of parameters analysed on antibody titre to pertussis, the Generalized Linear Model (GLZ) was used. Gender, type of vaccine, asthma, Hib and mumps antibody titres have been shown to be predictors of vaccine immunity to pertussis. Conclusions: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations. MDPI 2018-07-06 2018-07 /pmc/articles/PMC6068489/ /pubmed/29986481 http://dx.doi.org/10.3390/ijerph15071432 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bednarek, Anna
Bodajko-Grochowska, Anna
Hasiec, Barbara
Klepacz, Robert
Szczekala, Katarzyna
Zarzycka, Danuta
Emeryk, Andrzej
In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title_full In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title_fullStr In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title_full_unstemmed In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title_short In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children before the Administration of the First Booster
title_sort in search of factors negatively affecting vaccine immunity to pertussis in preschool children before the administration of the first booster
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068489/
https://www.ncbi.nlm.nih.gov/pubmed/29986481
http://dx.doi.org/10.3390/ijerph15071432
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