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Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands

[Image: see text] Positron emission tomography (PET) imaging of misfolded protein aggregates that form in neurodegenerative processes of the brain is key to providing a robust marker for improved diagnosis and evaluation of treatments. We report the development of advanced radiotracer candidates bas...

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Detalles Bibliográficos
Autores principales:	Rafique, Waqas, Kramer, Vasko, Pardo, Tania, Smits, René, Spilhaug, Mona M., Hoepping, Alexander, Savio, Eduardo, Engler, Henry, Kuljs, Rodrigo, Amaral, Horacio, Riss, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068598/ https://www.ncbi.nlm.nih.gov/pubmed/30087917 http://dx.doi.org/10.1021/acsomega.8b00975

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