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Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study

This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort. A total of 8237 participants in the Beijing Health Management Cohort study were recruited and surveyed during 2008–2009, and followed up in 2011–2012...

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Autores principales: Liu, Jia, Zhao, Zhan, Mu, Yongmin, Zou, Xiaoping, Zou, Dechun, Zhang, Jingbo, Chen, Shuo, Tao, Lixin, Guo, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068609/
https://www.ncbi.nlm.nih.gov/pubmed/30041483
http://dx.doi.org/10.3390/ijerph15071560
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author Liu, Jia
Zhao, Zhan
Mu, Yongmin
Zou, Xiaoping
Zou, Dechun
Zhang, Jingbo
Chen, Shuo
Tao, Lixin
Guo, Xiuhua
author_facet Liu, Jia
Zhao, Zhan
Mu, Yongmin
Zou, Xiaoping
Zou, Dechun
Zhang, Jingbo
Chen, Shuo
Tao, Lixin
Guo, Xiuhua
author_sort Liu, Jia
collection PubMed
description This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort. A total of 8237 participants in the Beijing Health Management Cohort study were recruited and surveyed during 2008–2009, and followed up in 2011–2012 and 2014–2015 surveys. Generalized estimating equation (GEE) models were used to evaluate the association between SUA and prediabetes. Furthermore, subgroup analyses assessed the primary outcome according to status of abdominal obesity, age and status of hypertension. During six years of follow-up, we identified 1083 prediabetes events. The GEE analyses confirmed and clarified the association between SUA and prediabetes (RR = 1.362; 95% CI = 1.095–1.696; p = 0.006) after adjusting for other potential confounders, especially in females (RR = 2.109; 95% CI = 1.329–3.347; p = 0.002). In addition, this association was stronger in the subgroup of females aged ≥48 years old (RR = 2.384; 95% CI = 1.417–4.010; p = 0.001). The risk for prediabetes increased significantly with increasing SUA for females in the Chinese population. This association was strongly confirmed in older females aged ≥48 years old rather than in younger females, which may provide clues for pathogenic mechanisms of gender differences in the association between SUA and prediabetes.
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spelling pubmed-60686092018-08-07 Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study Liu, Jia Zhao, Zhan Mu, Yongmin Zou, Xiaoping Zou, Dechun Zhang, Jingbo Chen, Shuo Tao, Lixin Guo, Xiuhua Int J Environ Res Public Health Article This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort. A total of 8237 participants in the Beijing Health Management Cohort study were recruited and surveyed during 2008–2009, and followed up in 2011–2012 and 2014–2015 surveys. Generalized estimating equation (GEE) models were used to evaluate the association between SUA and prediabetes. Furthermore, subgroup analyses assessed the primary outcome according to status of abdominal obesity, age and status of hypertension. During six years of follow-up, we identified 1083 prediabetes events. The GEE analyses confirmed and clarified the association between SUA and prediabetes (RR = 1.362; 95% CI = 1.095–1.696; p = 0.006) after adjusting for other potential confounders, especially in females (RR = 2.109; 95% CI = 1.329–3.347; p = 0.002). In addition, this association was stronger in the subgroup of females aged ≥48 years old (RR = 2.384; 95% CI = 1.417–4.010; p = 0.001). The risk for prediabetes increased significantly with increasing SUA for females in the Chinese population. This association was strongly confirmed in older females aged ≥48 years old rather than in younger females, which may provide clues for pathogenic mechanisms of gender differences in the association between SUA and prediabetes. MDPI 2018-07-23 2018-07 /pmc/articles/PMC6068609/ /pubmed/30041483 http://dx.doi.org/10.3390/ijerph15071560 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Jia
Zhao, Zhan
Mu, Yongmin
Zou, Xiaoping
Zou, Dechun
Zhang, Jingbo
Chen, Shuo
Tao, Lixin
Guo, Xiuhua
Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title_full Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title_fullStr Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title_full_unstemmed Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title_short Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study
title_sort gender differences in the association between serum uric acid and prediabetes: a six-year longitudinal cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068609/
https://www.ncbi.nlm.nih.gov/pubmed/30041483
http://dx.doi.org/10.3390/ijerph15071560
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