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Reversibility of diabetes mellitus: Narrative review of the evidence

The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimul...

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Autor principal: Ang, Gary Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068740/
https://www.ncbi.nlm.nih.gov/pubmed/30079148
http://dx.doi.org/10.4239/wjd.v9.i7.127
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author Ang, Gary Yee
author_facet Ang, Gary Yee
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description The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes patients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive medical management.
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spelling pubmed-60687402018-08-03 Reversibility of diabetes mellitus: Narrative review of the evidence Ang, Gary Yee World J Diabetes Minireviews The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes patients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive medical management. Baishideng Publishing Group Inc 2018-07-15 2018-07-15 /pmc/articles/PMC6068740/ /pubmed/30079148 http://dx.doi.org/10.4239/wjd.v9.i7.127 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Ang, Gary Yee
Reversibility of diabetes mellitus: Narrative review of the evidence
title Reversibility of diabetes mellitus: Narrative review of the evidence
title_full Reversibility of diabetes mellitus: Narrative review of the evidence
title_fullStr Reversibility of diabetes mellitus: Narrative review of the evidence
title_full_unstemmed Reversibility of diabetes mellitus: Narrative review of the evidence
title_short Reversibility of diabetes mellitus: Narrative review of the evidence
title_sort reversibility of diabetes mellitus: narrative review of the evidence
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068740/
https://www.ncbi.nlm.nih.gov/pubmed/30079148
http://dx.doi.org/10.4239/wjd.v9.i7.127
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