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Reversibility of diabetes mellitus: Narrative review of the evidence
The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimul...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068740/ https://www.ncbi.nlm.nih.gov/pubmed/30079148 http://dx.doi.org/10.4239/wjd.v9.i7.127 |
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author | Ang, Gary Yee |
author_facet | Ang, Gary Yee |
author_sort | Ang, Gary Yee |
collection | PubMed |
description | The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes patients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive medical management. |
format | Online Article Text |
id | pubmed-6068740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-60687402018-08-03 Reversibility of diabetes mellitus: Narrative review of the evidence Ang, Gary Yee World J Diabetes Minireviews The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes mellitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes patients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive medical management. Baishideng Publishing Group Inc 2018-07-15 2018-07-15 /pmc/articles/PMC6068740/ /pubmed/30079148 http://dx.doi.org/10.4239/wjd.v9.i7.127 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Ang, Gary Yee Reversibility of diabetes mellitus: Narrative review of the evidence |
title | Reversibility of diabetes mellitus: Narrative review of the evidence |
title_full | Reversibility of diabetes mellitus: Narrative review of the evidence |
title_fullStr | Reversibility of diabetes mellitus: Narrative review of the evidence |
title_full_unstemmed | Reversibility of diabetes mellitus: Narrative review of the evidence |
title_short | Reversibility of diabetes mellitus: Narrative review of the evidence |
title_sort | reversibility of diabetes mellitus: narrative review of the evidence |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068740/ https://www.ncbi.nlm.nih.gov/pubmed/30079148 http://dx.doi.org/10.4239/wjd.v9.i7.127 |
work_keys_str_mv | AT anggaryyee reversibilityofdiabetesmellitusnarrativereviewoftheevidence |